Using cbd cream has been shown to help relieve pain, particularly from arthritis. Its gentle formula, made from shea butter, aloe and hemp seed oil, deeply moisturizes the skin and makes it feel nourished. It contains a whopping 500 mg of CBD from full spectrum hemp extract and is rigorously lab-tested to ensure quality and safety. This balm has become a favorite of many people suffering from both osteoarthritis and rheumatoid arthritis, as well as other painful conditions like bursitis, sciatica, muscle strains and headaches.
It is recommended to apply cbd cream to the affected area, and then rub it in until absorbed. For maximum benefits, you should apply it daily as part of your routine, rather than sporadically. Studies show that applying CBD ointments twice daily for 3 months helped participants with psoriasis and eczema achieve improved results.
CBD’s anti-inflammatory effect on the skin is based on its ability to regulate the expression and activity of various genes, enzymatic systems, and receptors. This reduces the synthesis of pro-inflammatory molecules e.g. IL-1, IL-6, TNF-a and limits the activation of transcription factors e.g. NF-kB in cells Gegotek et al. 2021a.
The permeability of the skin’s barrier is affected by its thickness and composition, i.e. its lipid content and the presence of proteins. CBD is an effective emollient and improves the penetration of active ingredients into the skin by inhibiting the release of inflammatory mediators, and enhancing the formation of protective lipid adducts, such as phosphatidylserine. It also decreases the formation of oxidative stress products in keratinocytes, protecting them against UV-induced damage, by increasing cellular water retention through modulation of AQP3 and its protein partners Ikarashi et al. 2021.
The application of CBD to the skin has been shown to accelerate wound healing by reducing edema, increasing epidermis regeneration and deposition, collagen production and granulation tissue development. It has also been shown to reduce fibrosis formation in skin fibroblasts by limiting the production of TGF-b1, a cytokine that has profibrotic effects Lodzki et al. 2003.
CBD’s anti-fibrotic properties have also been shown to be beneficial in the treatment of a number of chronic and autoimmune diseases. CBD acts as a potent analgesic and can be used in conjunction with other pain relievers to reduce the severity of some types of chronic pain, including neuropathic pain, such as that associated with nerve disorders or multiple sclerosis. Moreover, CBD has been proven to be an effective analgesic for neuropathic and nociceptive pain in patients with cancer or HIV/AIDS Khan et al. 2019. However, more research is needed to confirm these promising findings. It is therefore important that you carefully select the product you purchase, ensuring it has third-party testing and that it does not make medical claims or provide medical advice. It is also recommended to consult a physician before starting any new health treatment.